Systematic Pharmacological Mechanisms of Biatractylolide Treating Vascular Dementia

Biatractylolide is an Atractylodes macrocephala derived bisesquiterpenoid that has been found treatment of dementia in model mice. This study aims to explore the therapeutic effect on vascular dementia. Network pharmacological techniques have used elaborate involved mechanisms biatractylolide treating Based PubChem database, Swiss target prediction and human gene database GeneCards, 19 common molecules were screened, they enriched many biological, such as Alzheimer’s disease corrective pathway, pathways neurodegeneration-multiple diseases, calcium signaling notch pathway endothelial growth factor pathway. Muscarinic acetylcholine receptor M1, amyloid-beta precursor protein, microtubule-associated protein tau, presenilin-1, presenilin-2, prostaglandin G/H synthase 2 disintegrin, metalloproteinase domain-containing 17 Protein–protein interaction network presents six highest degree nodes, phosphoinositide-3-kinase regulatory subunit 1, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic alpha, Harvey rat sarcoma virus, Jun N-terminal kinases, catenin beta mitogen-activated kinase 3 tumor P53, play core role four molecules, 14, Janus 2, tyrosine-protein phosphatase non-receptor type closely interact with biatractylolide. In addition, acetylcholinesterase was identified a strong suggests potential drug for or disease.